Capsaicin (8%) Patch Increases Multiple Electrical Nociceptive Perception Thresholds in Healthy Human Subjects
نویسندگان
چکیده
Background: Pre-operative nociceptive thresholds are able to predict patients susceptible to developing post-operative chronic pain. Thresholds are dependent on stimulus properties (i.e. pulsewidth (PW), number of pulses (NoP), and inter-pulse interval (IPI)) and are related to different mechanisms in the nociceptive system. Measuring multiple thresholds enables a detailed observation of peripheral and central nociceptive processing. In this study, a model of capsaicin defunctionalization was used to investigate the effect on multiple simultaneously measured electrical nociceptive perception thresholds.
منابع مشابه
Differentiating Nociceptive Mechanisms Using Electrocutaneous Detection Thresholds
Chronic pain after surgery is a frequent problem and difficult to treat. Patients at risk are not identified until early treatment is no longer effective. Persisting and chronic pain can be the result of the malfunctioning of nociceptive mechanisms; both ascending and descending pathways can, individually, attribute to chronic pain development [1]. Pain thresholds measured before and after surg...
متن کاملA randomized, controlled, open-label study of the long-term effects of NGX-4010, a high-concentration capsaicin patch, on epidermal nerve fiber density and sensory function in healthy volunteers.
UNLABELLED Desensitization of nociceptive sensory nerve endings is the basis for the therapeutic use of capsaicin in neuropathic pain syndromes. This study evaluated the pharmacodynamic effects of a single 60-minute application of NGX-4010, a high-concentration (8% w/w) capsaicin patch, on both thighs of healthy volunteers. Epidermal nerve fiber (ENF) density and quantitative sensory testing (Q...
متن کاملRole of hypocretin-1,2 (orexin A and B) in pain perception
Hypocretins/orexins are primary excitatory neuropeptides located exclusively in neurons of the lateral hypothalamic area, which send projections to most monoaminergic nuclei. It has been reported that i.c.v. injection of hypocretin 1 (orexin A) enhances wakefulness in rats and mice. The present work was carried out to examine the roles of hypocretins in nociception in mice. The presence of robu...
متن کاملDependence of Nociceptive Detection Thresholds on Physiological Parameters and Capsaicin-Induced Neuroplasticity: A Computational Study
Physiological properties of peripheral and central nociceptive subsystems can be altered over time due to medical interventions. The effective change for the whole nociceptive system can be reflected in changes of psychophysical characteristics, e.g., detection thresholds. However, it is challenging to separate contributions of distinct altered mechanisms with measurements of thresholds only. H...
متن کاملEffects of neonatal capsaicin treatment on nociceptive thresholds in the rat.
The responsiveness to noxious thermal, mechanical, and chemical stimuli was examined in adult rats that had been treated neonatally with capsaicin. A range of capsaicin doses was employed to determine whether the neurotoxicity of capsaicin to primary afferent fibers would be manifested behaviorally in a selective effect on nociceptive thresholds to specific stimuli. Animals were given 5 to 100 ...
متن کامل